Clinical significance refers to what aspect of treatment effect?

Clinical significance specifically addresses the practical importance of treatment effects in real-world contexts. It moves beyond mere statistical measures to focus on whether an effect is meaningful and beneficial in a patient's daily life. For a treatment to be considered clinically significant, it must lead to noticeable improvements in functioning and well-being that are relevant to the individual receiving the treatment.

While statistical reliability is important in assessing whether findings are consistent and replicable, it does not necessarily indicate that the results will translate into valuable changes in everyday experiences. Similarly, theoretical implications pertain more to the understanding of concepts and models rather than their application in practice. Lastly, while a large sample size can enhance the reliability and generalizability of study results, it alone does not determine the practical impact those results might have for individuals. Thus, the focus on practical importance aligns most closely with the concept of clinical significance.